In order to meet the increasing demand for biomarker-based testing solutions, these companies have undertaken several initiatives, such as conducting clinical trials, publishing research articles and expanding their existing capabilities / product portfolios.

The cancer biomarker market size is projected to grow from $ 28.6 billion in 2024 to $ 46.7 billion by 2035, representing a CAGR of 5% during the forecast period from 2024 to 2035.

Majority (66%) of the testing solutions use genomics technology for profiling cancer biomarkers. This can be attributed to the fact that genomics technology has the capability to provide extensive genetic information that can be utilized for early detection, prognosis, guiding treatment and developing targeted therapies.  Further, it is important to highlight that around 25% of the testing solutions use immunoassay for profiling cancer biomarkers. Examples of solutions that use genomics technology include (in alphabetical order) Cancer All-In-One Solid Tumor Assay (Agilent), CleanPlex TMB Panel (Paragon Genomics), GuardantOMNI (Guardant Health), MI Tumor Seek (Caris Life Sciences) and OmniSeq INSIGHT (Labcorp).

Turnaround time is defined as the total time between receiving a specimen at the laboratory and the final dispatch of the results to the customer. It is one of the most important parameters and is often used as a key performance indicator for evaluating the performance of a laboratory. We came across 21 testing solutions that have an average turnaround time of 10-15 days. Only a few testing solutions (10) have a turnaround time of less than 5 days; examples include (in alphabetical order) CleanPlex TMB Panel (Paragon Genomics), ddPCR Microsatellite Instability (MSI) Kit (Bio-Rad), FOXP3 Assay (PhenoPath) and IdyllaTM MSI Test (Biocartis).

Further, majority (73%) of the cancer biomarker testing solutions assists in the evaluation of MSI / MMR, followed by 47% testing solutions evaluating TMB. It is worth highlighting that over 35% of the testing solutions offer assessments for both MSI/MMR and TMB. Notable examples of testing solutions focused on the evaluation of both MSI / MMR and TMB include (in alphabetical order) Altera Comprehensive Genomic Profiling (Natera), CancerPrecision (CeGaT), FoundationOne CDx (Foundation Medicine), PGDx elio plasma complete (Personal Genome Diagnostics) and Tempus xT Solid Tumor (Tempus).

The field of cancer biomarkers has seen a significant rise in research, with over 470 articles published by various researchers, underscoring the growing focus of several industry players and academic players in this domain. During our research, we came across 476 articles focused on cancer biomarkers that have been published in this domain.

It is worth mentioning that the maximum number of articles were published in 2022, followed by articles published in the year 2023 (143). Notably, majority of the publications are focused on the diagnosis of lung cancer using cancer biomarkers. This is followed by articles published for breast cancer (15%), gastrointestinal cancer and kidney cancer (14% each).

In addition, the journal Nature Medicine emerged as the most popular journal with the highest impact factor of 87.241. This is followed by Journal of Clinical Oncology, with an impact factor of 50.717.

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